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Pyruvate minimizes rtPA toxicity from in vitro oxygen-glucose deprivation and reoxygenation
Clinical application of recombinant tissue plasminogen activator (rtPA) for stroke is limited by hemorrhagic transformation, which narrows rtPA’s therapeutic window. In addition, mounting evidence indicates that rtPA is potentially neurotoxic if it traverses a compromised blood brain barrier. Here,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007160/ https://ncbi.nlm.nih.gov/pubmed/23891792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2013.07.029 |
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