Pyruvate minimizes rtPA toxicity from in vitro oxygen-glucose deprivation and reoxygenation

Clinical application of recombinant tissue plasminogen activator (rtPA) for stroke is limited by hemorrhagic transformation, which narrows rtPA’s therapeutic window. In addition, mounting evidence indicates that rtPA is potentially neurotoxic if it traverses a compromised blood brain barrier. Here,...

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Detaylı Bibliyografya
Asıl Yazarlar: Ryou, Myoung-Gwi, Choudhury, Gourav Roy, Winters, Ali, Xie, Luokun, Mallet, Robert T., Yang, Shao-Hua
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007160/
https://ncbi.nlm.nih.gov/pubmed/23891792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2013.07.029
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