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Catechol-O-Methyltransferase and 3,4-(±)-Methylenedioxymethamphetamine Toxicity

Metabolism of 3,4-(±)-methylenedioxymethamphetamine (MDMA) is necessary to elicit its neurotoxic effects. Perturbations in phase I and phase II hepatic enzymes can alter the neurotoxic profile of systemically administered MDMA. In particular, catechol-O-methyltransferase (COMT) plays a critical role...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Herndon, Joseph M., Cholanians, Aram B., Lizarraga, Lucina E., Lau, Serrine S., Monks, Terrence J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007109/
https://ncbi.nlm.nih.gov/pubmed/24591155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu035
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