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Catechol-O-Methyltransferase and 3,4-(±)-Methylenedioxymethamphetamine Toxicity
Metabolism of 3,4-(±)-methylenedioxymethamphetamine (MDMA) is necessary to elicit its neurotoxic effects. Perturbations in phase I and phase II hepatic enzymes can alter the neurotoxic profile of systemically administered MDMA. In particular, catechol-O-methyltransferase (COMT) plays a critical role...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007109/ https://ncbi.nlm.nih.gov/pubmed/24591155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu035 |
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