Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

Mushroom dendritic spine structures are essential for memory storage and the loss of mushroom spines may explain memory defects in Alzheimer's disease (AD). Here we show a significant reduction in the fraction of mushroom spines in hippocampal neurons from the presenilin-1 M146V knockin (KI) mo...

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Sonraí Bibleagrafaíochta
Main Authors: Sun, Suya, Zhang, Hua, Liu, Jie, Popugaeva, Elena, Xu, Nan-Jie, Feske, Stefan, White, Charles L., Bezprozvanny, Ilya
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007018/
https://ncbi.nlm.nih.gov/pubmed/24698269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.02.019
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