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Wise Regulates Bone Deposition through Genetic Interactions with Lrp5
In this study using genetic approaches in mouse we demonstrate that the secreted protein Wise plays essential roles in regulating early bone formation through its ability to modulate Wnt signaling via interactions with the Lrp5 co-receptor. In Wise(−/−) mutant mice we find an increase in the rate of...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4006890/ https://ncbi.nlm.nih.gov/pubmed/24789067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096257 |
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