Lrp5 functions in bone to regulate bone mass

The human skeleton is affected by mutations in Low-density lipoprotein Receptor-related Protein 5 (LRP5). To understand how LRP5 influences bone properties, we generated mice with inducible Lrp5 mutations that cause high bone mass and low bone mass phenotypes in humans. We conditionally-induced Lrp5...

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Detalhes bibliográficos
Main Authors: Cui, Yajun, Niziolek, Paul J., MacDonald, Bryan T., Zylstra, Cassandra R., Alenina, Natalia, Robinson, Daniel R., Zhong, Zhendong, Matthes, Susann, Jacobsen, Christina M., Conlon, Ronald A., Brommage, Robert, Liu, Qingyun, Mseeh, Faika, Powell, David R., Yang, Qi, Zambrowicz, Brian, Gerrits, Han, Gossen, Jan A., He, Xi, Bader, Michael, Williams, Bart O., Warman, Matthew L., Robling, Alexander G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113461/
https://ncbi.nlm.nih.gov/pubmed/21602802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2388
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