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Development and Validation of a High-Content Bimolecular Fluorescence Complementation Assay for Small Molecule Inhibitors of HIV-1 Nef Dimerization

Nef is an HIV-1 accessory factor essential for viral pathogenesis and AIDS progression. Many Nef functions require dimerization, and small molecules that block Nef dimerization may represent antiretroviral drug leads. Here we describe a cell-based assay for Nef dimerization inhibitors based on bimol...

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Bibliografski detalji
Glavni autori: Poe, Jerrod A., Vollmer, Laura, Vogt, Andreas, Smithgall, Thomas E.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006692/
https://ncbi.nlm.nih.gov/pubmed/24282155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057113513640
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