α2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cells

AIM: We aimed to investigate the potential modification of previously unrecognized surface glycoprotein(s) by α2,6-sialylation other than by integrins. METHODS: The expression of β-galactoside α2,6-sialyltransferase (ST6Gal-I) in the colon cancer cell line HCT116 was reduced by siRNA. The adhesion a...

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Autors principals: Qian, Jin, Zhu, Cai-hua, Tang, Shuai, Shen, Ai-jun, Ai, Jing, Li, Jing, Geng, Mei-yu, Ding, Jian
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006660/
https://ncbi.nlm.nih.gov/pubmed/19483716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.84
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