Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells

AIM: The ubiquitin-proteasome system (UPS) and lysosome-dependent macroautophagy (autophagy) are two major intracellular pathways for protein degradation. Recent studies suggest that proteasome inhibitors may reduce tumor growth and activate autophagy. Due to the dual roles of autophagy in tumor cel...

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Bibliographic Details
Main Authors: Ge, Peng-fei, Zhang, Ji-zhou, Wang, Xiao-fei, Meng, Fan-kai, Li, Wen-chen, Luan, Yong-xin, Ling, Feng, Luo, Yi-nan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006657/
https://ncbi.nlm.nih.gov/pubmed/19575007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.71
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