The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells

AIM: Statin disposition and response are greatly determined by the activities of drug metabolizing enzymes and efflux/ uptake transporters. There is little information on the regulation of these proteins in human cells after statin therapy. In this study, the effects of atorvastatin and simvastatin...

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Bibliographische Detailangaben
Hauptverfasser: Rodrigues, Alice Cristina, Curi, Rui, Genvigir, Fabiana Dalla Vecchia, Hirata, Mario Hiroyuki, Hirata, Rosario Dominguez Crespo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006650/
https://ncbi.nlm.nih.gov/pubmed/19543298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.85
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