The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells

AIM: Statin disposition and response are greatly determined by the activities of drug metabolizing enzymes and efflux/ uptake transporters. There is little information on the regulation of these proteins in human cells after statin therapy. In this study, the effects of atorvastatin and simvastatin...

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Main Authors: Rodrigues, Alice Cristina, Curi, Rui, Genvigir, Fabiana Dalla Vecchia, Hirata, Mario Hiroyuki, Hirata, Rosario Dominguez Crespo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006650/
https://ncbi.nlm.nih.gov/pubmed/19543298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.85
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