Identification of seven loci affecting mean telomere length and their association with disease

Inter-individual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases. Here, in a genome-wide meta-analysis of 37,684 individuals with replication of selected variants in a further 10,739 individuals, we identified seven loci, including five...

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المؤلفون الرئيسيون: Codd, Veryan, Nelson, Christopher P., Albrecht, Eva, Mangino, Massimo, Deelen, Joris, Buxton, Jessica L., Jan Hottenga, Jouke, Fischer, Krista, Esko, Tõnu, Surakka, Ida, Broer, Linda, Nyholt, Dale R., Mateo Leach, Irene, Salo, Perttu, Hägg, Sara, Matthews, Mary K., Palmen, Jutta, Norata, Giuseppe D., O’Reilly, Paul F., Saleheen, Danish, Amin, Najaf, Balmforth, Anthony J., Beekman, Marian, de Boer, Rudolf A., Böhringer, Stefan, Braund, Peter S., Burton, Paul R., de Craen, Anton J. M., Denniff, Matthew, Dong, Yanbin, Douroudis, Konstantinos, Dubinina, Elena, Eriksson, Johan G., Garlaschelli, Katia, Guo, Dehuang, Hartikainen, Anna-Liisa, Henders, Anjali K., Houwing-Duistermaat, Jeanine J., Kananen, Laura, Karssen, Lennart C., Kettunen, Johannes, Klopp, Norman, Lagou, Vasiliki, van Leeuwen, Elisabeth M., Madden, Pamela A., Mägi, Reedik, Magnusson, Patrik K.E., Männistö, Satu, McCarthy, Mark I., Medland, Sarah E., Mihailov, Evelin, Montgomery, Grant W., Oostra, Ben A., Palotie, Aarno, Peters, Annette, Pollard, Helen, Pouta, Anneli, Prokopenko, Inga, Ripatti, Samuli, Salomaa, Veikko, Suchiman, H. Eka D., Valdes, Ana M., Verweij, Niek, Viñuela, Ana, Wang, Xiaoling, Wichmann, H.-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wright, Margaret J., Xia, Kai, Xiao, Xiangjun, van Veldhuisen, Dirk J., Catapano, Alberico L., Tobin, Martin D., Hall, Alistair S., Blakemore, Alexandra I.F., van Gilst, Wiek H., Zhu, Haidong, Erdmann, Jeanette, Reilly, Muredach P., Kathiresan, Sekar, Schunkert, Heribert, Talmud, Philippa J., Pedersen, Nancy L., Perola, Markus, Ouwehand, Willem, Kaprio, Jaakko, Martin, Nicholas G., van Duijn, Cornelia M., Hovatta, Iiris, Gieger, Christian, Metspalu, Andres, Boomsma, Dorret I., Jarvelin, Marjo-Riitta, Slagboom, P. Eline, Thompson, John R., Spector, Tim D., van der Harst, Pim, Samani, Nilesh J.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2013
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006270/
https://ncbi.nlm.nih.gov/pubmed/23535734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2528
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