Mechanisms of Action of Acetaldehyde in the Up-Regulation of the Human α2(I) Collagen Gene in Hepatic Stellate Cells: Key Roles of Ski, SMAD3, SMAD4, and SMAD7

Alcohol-induced liver fibrosis and eventually cirrhosis is a leading cause of death. Acetaldehyde, the first metabolite of ethanol, up-regulates expression of the human α2(I) collagen gene (COL1A2). Early acetaldehyde-mediated effects involve phosphorylation and nuclear translocation of SMAD3/4–cont...

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Detalhes bibliográficos
Main Authors: Reyes-Gordillo, Karina, Shah, Ruchi, Arellanes-Robledo, Jaime, Hernández-Nazara, Zamira, Rincón-Sánchez, Ana Rosa, Inagaki, Yutaka, Rojkind, Marcos, Lakshman, M. Raj
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2014
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005982/
https://ncbi.nlm.nih.gov/pubmed/24641900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.01.020
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