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Design of antiviral stapled peptides containing a biphenyl cross-linker

Here we report the design and synthesis of a panel of stapled peptides containing a distance-matching biphenyl cross-linker based upon a peptide capsid assembly inhibitor reported previously. Compared with the linear peptide, the biphenyl-stapled peptides exhibited significantly enhanced cell penetr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Muppidi, Avinash, Zhang, Hongtao, Curreli, Francesca, Li, Nan, Debnath, Asim K., Lin, Qing
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005879/
https://ncbi.nlm.nih.gov/pubmed/24613163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.02.038
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