5′-O-Methylphosphonate nucleic acids—new modified DNAs that increase the Escherichia coli RNase H cleavage rate of hybrid duplexes

Several oligothymidylates containing various ratios of phosphodiester and isopolar 5′-hydroxyphosphonate, 5′-O-methylphosphonate and 3′-O-methylphosphonate internucleotide linkages were examined with respect to their hybridization properties with oligoriboadenylates and their ability to induce RNA c...

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Bibliographic Details
Main Authors: Šípová, Hana, Špringer, Tomáš, Rejman, Dominik, Šimák, Ondřej, Petrová, Magdalena, Novák, Pavel, Rosenbergová, Šárka, Páv, Ondřej, Liboska, Radek, Barvík, Ivan, Štěpánek, Josef, Rosenberg, Ivan, Homola, Jiří
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Synthetic Biology and Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005664/
https://ncbi.nlm.nih.gov/pubmed/24523351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku125
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