Inhibition of Human Immunodeficiency Virus Type 1 Tat-trans-Activation-Responsive Region Interaction by an Antiviral Quinolone Derivative

WM5, a 6-aminoquinolone derivative, binds with high affinity to the bulge of the trans-activation-responsive region (TAR), whereas it displays low binding affinity for the loop and stem regions of TAR and for random RNA and DNA sequences. Furthermore, WM5 disrupts the natural protein-nucleic acid co...

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Detalhes bibliográficos
Main Authors: Richter, Sara, Parolin, Cristina, Gatto, Barbara, Del Vecchio, Claudia, Brocca-Cofano, Egidio, Fravolini, Arnaldo, Palù, Giorgio, Palumbo, Manlio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC400552/
https://ncbi.nlm.nih.gov/pubmed/15105155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1895-1899.2004
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