IL-4 receptor alpha single-nucleotide polymorphisms rs1805010 and rs1801275 are associated with increased risk of asthma in a Saudi Arabian population

BACKGROUND: The IL-4 receptor alpha subunit (IL-4Rα), when associated with the common gamma chain receptor, or the IL-13Rα1 subunit, transduces signals to STAT6 in response to IL-4 and IL-13 stimulations. This results in a number of cell-specific responses including Th2 differentiation, lymphocyte p...

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Autores principales: Al-Muhsen, Saleh, Vazquez-Tello, Alejandro, Alzaabi, Ashraf, Al-Hajjaj, Mohamed S., Al-Jahdali, Hamdan H., Halwani, Rabih
Formato: Artigo
Lenguaje:Inglês
Publicado: Medknow Publications & Media Pvt Ltd 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005166/
https://ncbi.nlm.nih.gov/pubmed/24791170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1817-1737.128849
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