Disrupting the Interaction of BRD4 with Di-acetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer

Twist is a key transcription activator of epithelial-mesenchymal transition (EMT). It remains unclear how Twist induces gene expression. Here we reported a mechanism by which Twist recruits BRD4 to direct WNT5A expression in basal-like breast cancer (BLBC). Twist contains a “histone H4 mimic” GK-X-G...

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Autori principali: Shi, Jian, Wang, Yifan, Zeng, Lei, Wu, Yadi, Deng, Jiong, Zhang, Qiang, Lin, Yiwei, Li, Junlin, Kang, Tiebang, Tao, Min, Rusinova, Elena, Zhang, Guangtao, Wang, Chi, Zhu, Haining, Yao, Jun, Zeng, Yi-Xin, Evers, B. Mark, Zhou, Ming-Ming, Zhou, Binhua P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004960/
https://ncbi.nlm.nih.gov/pubmed/24525235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.01.028
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