Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

Advocacy for better drugs and access to treatment has boosted the interest in drug discovery and development for Chagas disease, a chronic infection caused by the genetically heterogeneous parasite, Trypanosoma cruzi. In this work new in vitro assays were used to gain a better understanding of the a...

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Bibliographic Details
Main Authors: Moraes, Carolina B., Giardini, Miriam A., Kim, Hwayoung, Franco, Caio H., Araujo-Junior, Adalberto M., Schenkman, Sergio, Chatelain, Eric, Freitas-Junior, Lucio H.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004771/
https://ncbi.nlm.nih.gov/pubmed/24736467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04703
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