Cellular and humoral immunity in arthritis are profoundly influenced by the interaction between cigarette smoke effects and host HLA-DR and DQ genes

Individuals carrying DRB1*0401 who smoke cigarettes are at an increased risk of developing severe seropositive RA. To determine how cigarette smoke (CS) interacts with host genetic factors in the induction of RA-associated autoimmunity, we used transgenic mice carrying the RA-susceptible HLA genes D...

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Main Authors: Vassallo, Robert, Luckey, David, Behrens, Marshall, Madden, Benjamin, Luthra, Harvinder, David, Chella, Taneja, Veena
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004713/
https://ncbi.nlm.nih.gov/pubmed/24631425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2014.02.002
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