Reduced Intranuclear Mobility of APL Fusion Proteins Accompanies Their Mislocalization and Results in Sequestration and Decreased Mobility of Retinoid X Receptor α

Acute promyelocytic leukemia (APL) cells contain one of five chimeric retinoic acid α-receptor (RARα) genes (X-RARα) created by chromosomal translocations or deletion; each generates a fusion protein thought to transcriptionally repress RARα target genes and block myeloid differentiation by an incom...

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Main Authors: Dong, Shuo, Stenoien, David L., Qiu, Jihui, Mancini, Michael A., Tweardy, David J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Transcriptional Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC400470/
https://ncbi.nlm.nih.gov/pubmed/15121864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.10.4465-4475.2004
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