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AUGMENTED S-NITROSYLATION CONTRIBUTES TO IMPAIRED RELAXATION IN ANGIOTENSIN II HYPERTENSIVE MOUSE AORTA: ROLE OF THIOREDOXIN REDUCTASE

Vascular dysfunction, including reduced endothelium-dependent dilation, is a major characteristic of hypertension. We previously investigated that TrxR inhibition impairs vasodilation via soluble guanylyl cyclase S-nitrosylation, but S-nitrosylation and TrxR function are not known in hypertension. W...

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Detalhes bibliográficos
Main Authors: Choi, Hyehun, Allahdadi, Kyan J., Tostes, Rita C., Webb, R. Clinton
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004364/
https://ncbi.nlm.nih.gov/pubmed/22025239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0b013e32834d2554
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