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Elucidating a Key Component of Cancer Metastasis: CXCL12 (SDF-1α) Binding to CXCR4

[Image: see text] The chemotactic signaling induced by the binding of chemokine CXCL12 (SDF-1α) to chemokine receptor CXCR4 is of significant biological importance and is a potential therapeutic axis against HIV-1. However, as CXCR4 is overexpressed in certain cancer cells, the CXCL12:CXCR4 signalin...

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Bibliografische gegevens
Hoofdauteurs: Tamamis, Phanourios, Floudas, Christodoulos A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2014
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004218/
https://ncbi.nlm.nih.gov/pubmed/24660779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci500069y
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