Molecular Recognition of CXCR4 by a Dual Tropic HIV-1 gp120 V3 Loop

HIV-1 cell entry is initiated by the interaction of the viral envelope glycoprotein gp120 with CD4, and chemokine coreceptors CXCR4 and CCR5. The molecular recognition of CXCR4 or CCR5 by the HIV-1 gp120 is mediated through the V3 loop, a fragment of gp120. The binding of the V3 loop to CXCR4 or CCR...

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Bibliographic Details
Main Authors: Tamamis, Phanourios, Floudas, Christodoulos A.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2013
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785887/
https://ncbi.nlm.nih.gov/pubmed/24048002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.07.049
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