Sensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RARα promoter region

All-trans retinoic acid (ATRA) is well established as differentiation therapy for acute promyelocytic leukemia (APL) in which the PML–RARα (promyelocytic leukemia-retinoic acid receptor α) fusion protein causes blockade of the retinoic acid (RA) pathway; however, in types of acute myeloid leukemia (...

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Detalhes bibliográficos
Main Authors: Sakamoto, K, Imamura, T, Yano, M, Yoshida, H, Fujiki, A, Hirashima, Y, Hosoi, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003419/
https://ncbi.nlm.nih.gov/pubmed/24769646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.25
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