Initiation of MLL-rearranged AML is dependent on C/EBPα

MLL-fusion proteins are potent inducers of oncogenic transformation, and their expression is considered to be the main oncogenic driving force in ∼10% of human acute myeloid leukemia (AML) patients. These oncogenic fusion proteins are responsible for the initiation of a downstream transcriptional pr...

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Autors principals: Ohlsson, Ewa, Hasemann, Marie Sigurd, Willer, Anton, Lauridsen, Felicia Kathrine Bratt, Rapin, Nicolas, Jendholm, Johan, Porse, Bo Torben
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2014
Matèries:
Brief Definitive Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892979/
https://ncbi.nlm.nih.gov/pubmed/24367003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130932
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