Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 virus

Recently, A/H5N1 influenza viruses were shown to acquire airborne transmissibility between ferrets upon targeted mutagenesis and virus passage. The critical genetic changes in airborne A/Indonesia/5/05 were not yet identified. Here, five substitutions proved to be sufficient to determine this airbor...

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Main Authors: Linster, Martin, van Boheemen, Sander, de Graaf, Miranda, Schrauwen, Eefje J. A., Lexmond, Pascal, Mänz, Benjamin, Bestebroer, Theo M., Baumann, Jan, van Riel, Debby, Rimmelzwaan, Guus F., Osterhaus, Albert D.M.E., Matrosovich, Mikhail, Fouchier, Ron A. M., Herfst, Sander
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003409/
https://ncbi.nlm.nih.gov/pubmed/24725402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.02.040
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