Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 virus

Recently, A/H5N1 influenza viruses were shown to acquire airborne transmissibility between ferrets upon targeted mutagenesis and virus passage. The critical genetic changes in airborne A/Indonesia/5/05 were not yet identified. Here, five substitutions proved to be sufficient to determine this airbor...

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Detalhes bibliográficos
Main Authors: Linster, Martin, van Boheemen, Sander, de Graaf, Miranda, Schrauwen, Eefje J. A., Lexmond, Pascal, Mänz, Benjamin, Bestebroer, Theo M., Baumann, Jan, van Riel, Debby, Rimmelzwaan, Guus F., Osterhaus, Albert D.M.E., Matrosovich, Mikhail, Fouchier, Ron A. M., Herfst, Sander
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003409/
https://ncbi.nlm.nih.gov/pubmed/24725402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.02.040
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