Ouabain facilitates cardiac differentiation of mouse embryonic stem cells through ERK1/2 pathway

AIM: To investigate the effects of the cardiotonic steroid, ouabain, on cardiac differentiation of murine embyronic stem cells (mESCs). METHODS: Cardiac differentiation of murine ESCs was enhanced by standard hanging drop method in the presence of ouabain (20 μmol/L) for 7 d. The dissociated ES deri...

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Main Authors: Lee, Yee-Ki, Ng, Kwong-Man, Lai, Wing-Hon, Man, Cornelia, Lieu, Deborah K, Lau, Chu-Pak, Tse, Hung-Fat, Siu, Chung-Wah
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003319/
https://ncbi.nlm.nih.gov/pubmed/21151160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.188
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