Novel selective cannabinoid CB(1) receptor antagonist MJ08 with potent in vivo bioactivity and inverse agonistic effects

AIM: To characterize the biological profiles of MJ08, a novel selective CB(1) receptor antagonist. METHODS: Radioligand binding assays were performed using rat brain and spleen membrane preparations. CB(1) and CB(2) receptor redistribution and intracellular Ca(2+) ([Ca(2+)](i)) assays were performed...

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Autores principales: Chen, Wei, Xu, Cheng, Liu, Hong-ying, Long, Long, Zhang, Wei, Zheng, Zhi-bing, Xie, Yun-de, Wang, Li-li, Li, Song
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003302/
https://ncbi.nlm.nih.gov/pubmed/21841814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.80
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