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Novel selective cannabinoid CB(1) receptor antagonist MJ08 with potent in vivo bioactivity and inverse agonistic effects
AIM: To characterize the biological profiles of MJ08, a novel selective CB(1) receptor antagonist. METHODS: Radioligand binding assays were performed using rat brain and spleen membrane preparations. CB(1) and CB(2) receptor redistribution and intracellular Ca(2+) ([Ca(2+)](i)) assays were performed...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4003302/ https://ncbi.nlm.nih.gov/pubmed/21841814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.80 |
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