Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis

AIM: The hypoxic condition within large or infiltrative hypovascular tumors produces intracellular acidification, which could activate many signaling pathways and augment cancer cell growth and invasion. Carbonic anhydrase-IX (CA-IX) is an enzyme lowering pH. This study is to examine whether hypoxia...

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Detalhes bibliográficos
Main Authors: Yu, Su-jong, Yoon, Jung-hwan, Lee, Jeong-hoon, Myung, Sun-jung, Jang, Eun-sun, Kwak, Min-sun, Cho, Eun-ju, Jang, Ja-june, Kim, Yoon-jun, Lee, Hyo-suk
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003119/
https://ncbi.nlm.nih.gov/pubmed/21666701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.24
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