LLDT-67 attenuates MPTP-induced neurotoxicity in mice by up-regulating NGF expression

AIM: To investigate the neuroprotective effects of LLDT-67, a novel derivative of triptolide, in MPTP-induced mouse Parkinson's disease (PD) models and in primary cultured astrocytes, and to elucidate the mechanisms of the action. METHODS: In order to induce PD, C57BL/6 mice were injected MPTP...

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Detalhes bibliográficos
Main Authors: Wu, Dong-dong, Huang, Li, Zhang, Lei, Wu, Le-yu, Li, Yuan-chao, Feng, Linyin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003115/
https://ncbi.nlm.nih.gov/pubmed/22941283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.88
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