Immobilized MHC class I chain-related protein A synergizes with IL-15 and soluble 4-1BB ligand to expand NK cells with high cytotoxicity ex vivo

Major histocompatibility complex (MHC) class I chain-related protein A (MICA), which is a ligand for human NKG2D, is expressed by a variety of epithelial tumor cells and promotes the activation of natural killer (NK), CD8(+) and γδ-T cells. Although ectopic expression of MICA on tumor cells elicits...

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Detalhes bibliográficos
Main Authors: Gong, Weijuan, Xiao, Weiming, Qian, Li, Gong, Chunxiang, Hu, Maozhi, Pan, Xianyuan, Ji, Mingchun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002957/
https://ncbi.nlm.nih.gov/pubmed/20871627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2010.41
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