Effects of NS1 variants of H5N1 influenza virus on interferon induction, TNFα response and p53 activity

Non-structural protein 1 (NS1) is an important virulence factor of the highly pathogenic H5N1 avian influenza virus. A five-amino-acid (5 aa) deletion at position 80–84 and an aspartic acid to glutamic acid substitution at position 92 (D92E) are two major NS1 mutations that are highly correlated wit...

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Autori principali: Li, Weizhong, Wang, Gefei, Zhang, Heng, Xin, Gang, Zhang, Dangui, Zeng, Jun, Chen, Xiaoxuan, Xu, Yanxuan, Cui, Youhong, Li, Kangsheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002919/
https://ncbi.nlm.nih.gov/pubmed/20228833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2010.6
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