Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition

BACKGROUND: Phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, activated during influenza A virus infection, can promote viral replication via multiple mechanisms. Direct binding of NS1 protein to p85β subunit of PI3K is required for activation of PI3K/Akt signaling. Binding and subsequent...

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Detalhes bibliográficos
Main Authors: Li, Weizhong, Wang, Gefei, Zhang, Heng, Shen, Yanqin, Dai, Jianping, Wu, Liqi, Zhou, Jianxiang, Jiang, Zhiwu, Li, Kangsheng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416684/
https://ncbi.nlm.nih.gov/pubmed/22530768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1297-9716-43-36
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