Expression of a dominant-negative Rho-kinase promotes neurite outgrowth in a microenvironment mimicking injured central nervous system

AIM: To investigate whether lentiviral vector (LV)-mediated expression of a dominant negative mutant Rho-kinase (DNROCK) could inhibit activation of the Rho/ROCK signaling pathway and promote neurite outgrowth in a hostile microenvironment mimicking the injured central nervous system (CNS) in vitro....

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Bibliographic Details
Main Authors: Yang, Ping, Wen, Hui-zhong, Zhang, Jin-hai
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002750/
https://ncbi.nlm.nih.gov/pubmed/20383168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.35
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