HIF-1α links β-adrenoceptor agonists and pancreatic cancer cells under normoxic condition

AIM: To examine whether β-adrenoceptor (β-AR) agonists can induce hypoxia-inducible factor (HIF)-1α accumulation which then up-regulate the expression of its target genes in pancreatic cancer cells at normoxia, and to further elucidate the mechanism involved. METHODS: Pulse-chase assay, RT-PCR, and...

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Detalhes bibliográficos
Main Authors: Hu, Heng-tong, Ma, Qing-yong, Zhang, Dong, Shen, Su-gang, Han, Liang, Ma, Ya-dong, Li, Ruo-fei, Xie, Ke-ping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002695/
https://ncbi.nlm.nih.gov/pubmed/20037603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.181
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