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Molecular modeling, quantum polarized ligand docking and structure-based 3D-QSAR analysis of the imidazole series as dual AT(1) and ET(A) receptor antagonists
AIM: Both endothelin ET(A) receptor antagonists and angiotensin AT(1) receptor antagonists lower blood pressure in hypertensive patients. A dual AT(1) and ET(A) receptor antagonist may be more efficacious antihypertensive drug. In this study we identified the mode and mechanism of binding of imidazo...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4002566/ https://ncbi.nlm.nih.gov/pubmed/24304920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.129 |
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