Molecular modeling, quantum polarized ligand docking and structure-based 3D-QSAR analysis of the imidazole series as dual AT(1) and ET(A) receptor antagonists

AIM: Both endothelin ET(A) receptor antagonists and angiotensin AT(1) receptor antagonists lower blood pressure in hypertensive patients. A dual AT(1) and ET(A) receptor antagonist may be more efficacious antihypertensive drug. In this study we identified the mode and mechanism of binding of imidazo...

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Hlavní autoři: Singh, Khuraijam Dhanachandra, Muthusamy, Karthikeyan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002566/
https://ncbi.nlm.nih.gov/pubmed/24304920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.129
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