Sulfated polymannuroguluronate inhibits Tat-induced SLK cell adhesion via a novel binding site, a KKR spatial triad

AIM: Sulfated polymannuroguluronate (SPMG), a candidate anti-AIDS drug, inhibited HIV replication and interfered with HIV entry into host T lymphocytes. SPMG has high binding affinity for the transactivating factor of the HIV-1 virus (Tat) via its basic domain. However, deletion or substitution of t...

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Main Authors: Wu, Yan-lin, Ai, Jing, Zhao, Jing-ming, Xiong, Bing, Xin, Xiao-jie, Geng, Mei-yu, Xin, Xian-liang, Jiang, Han-dong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002517/
https://ncbi.nlm.nih.gov/pubmed/21499289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.2
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