Pharmacokinetics of CTLA4Ig fusion protein in healthy volunteers and patients with rheumatoid arthritis

AIM: To evaluate single-dose and multiple-dose pharmacokinetics of cytotoxic T-lymphocyte-associated antigen 4 fusion protein (CTLA4Ig) in healthy volunteers and patients with rheumatoid arthritis (RA). METHODS: The clinical trials included two phase I open studies: study 1 was an open-label dose-es...

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Main Authors: Ma, Ying, Lin, Bi-rong, Lin, Bei, Hou, Sheng, Qian, Wei-zhu, Li, Jing, Tan, Min, Ma, Jian, Li, Bo-hua, Wang, Hao, Wen, Ai-dong, Guo, Ya-jun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002403/
https://ncbi.nlm.nih.gov/pubmed/19262560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.13
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