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Structural changes of tumor necrosis factor alpha associated with membrane insertion and channel formation.

Low pH enhances tumor necrosis factor alpha (TNF)-induced cytolysis of cancer cells and TNF-membrane interactions that include binding, insertion, and ion-channel formation. We have also found that TNF increases Na+ influx in cells. Here, we examined the structural features of the TNF-membrane inter...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Baldwin, R L, Stolowitz, M L, Hood, L, Wisnieski, B J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40023/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8577707/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.3.1021
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