Thioredoxin-interacting Protein Promotes Islet Amyloid Polypeptide Expression through miR-124a and FoxA2

Thioredoxin-interacting protein (TXNIP) is up-regulated by glucose and diabetes and plays a critical role in glucotoxicity, inflammation, and beta-cell apoptosis, whereas we have found that TXNIP deficiency protects against diabetes. Interestingly, human islet amyloid polypeptide (IAPP) is also indu...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Jing, Gu, Westwell-Roper, Clara, Chen, Junqin, Xu, Guanlan, Verchere, C. Bruce, Shalev, Anath
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2014
נושאים:
Gene Regulation
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002088/
https://ncbi.nlm.nih.gov/pubmed/24627476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.525022
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