Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) and PH Domain and Leucine-rich Repeat Phosphatase Cross-talk (PHLPP) in Cancer Cells and in Transforming Growth Factor β-Activated Stem Cells

Akt kinase controls cell survival, proliferation, and invasive growth and is a critical factor for cancer development. Here we describe a cross-talk between phosphatases that may preserve levels of activated/phosphorylated Akt and confer aggressive growth of cancer cells. In prostatic cancer cells,...

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Bibliographic Details
Main Authors: Ghalali, Aram, Ye, Zhi-wei, Högberg, Johan, Stenius, Ulla
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002071/
https://ncbi.nlm.nih.gov/pubmed/24599953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537241
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