Blockade of CD28 by a synthetical peptoid inhibits T-cell proliferation and attenuates graft-versus-host disease

CD28 is one of the costimulatory molecules crucial for T-cell activation and thus has become an attractive target for therapeutic immunomodulation. Conventional strategies for blocking CD28 activity using monoclonal antibodies, Fab fragments, antagonistic peptide and fusion proteins, have apparent d...

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Main Authors: Li, Na, Zhu, Faliang, Gao, Fei, Wang, Qun, Wang, Xiaoyan, Li, Haiyan, Ma, Chunhong, Sun, Wensheng, Xu, Wenfang, Wang, Chaodong, Zhang, Lining
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001891/
https://ncbi.nlm.nih.gov/pubmed/20140006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2009.120
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