L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells

AIM: To identify a small molecule L655,240 as a novel β-secretase (BACE1) inhibitor and to investigate its effects on β-amyloid (Aβ) generation in vitro. METHODS: Fluorescence resonance energy transfer (FRET) was used to characterize the inhibitory effect of L655,240 on BACE1. Surface plasmon resona...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lu, Qin, Chen, Wu-yan, Zhu, Zhi-yuan, Chen, Jing, Xu, Ye-chun, Kaewpet, Morakot, Rukachaisirikul, Vatcharin, Chen, Li-li, Shen, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001842/
https://ncbi.nlm.nih.gov/pubmed/22842730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.74
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados