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PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes
The PI3K-Akt pathway is a vital regulator of cell proliferation and survival. Alterations in the PIK3CA gene that lead to enhanced PI3K kinase activity have been reported in many human cancer types, including cancers of the colon, breast, brain, liver, stomach and lung. Deregulation of PI3K causes a...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4001841/ https://ncbi.nlm.nih.gov/pubmed/22983389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.72 |
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