Angiotensin II regulates the LARG/RhoA/MYPT1 axis in rat vascular smooth muscle in vitro

AIM: To identify a key protein that binds monomeric G protein RhoA and activates the RhoA/Rho kinase/MYPT1 axis in vascular smooth muscle cells (VSMCs) upon angiotensin II (Ang II) stimulation. METHODS: Primary cultured VSMCs from Sprague-Dawley rats were transfected with siRNAs against leukemia-ass...

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Autors principals: Chiu, Wei-chiao, Juang, Jyh-ming, Chang, Shen-nan, Wu, Cho-kai, Tsai, Chia-ti, Tseng, Yung-zu, Chiang, Fu-tien
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001838/
https://ncbi.nlm.nih.gov/pubmed/23123644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.117
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