A Statin-Loaded Reconstituted High-Density Lipoprotein Nanoparticle Inhibits Atherosclerotic Plaque Inflammation

Inflammation is a key feature of atherosclerosis and a target for therapy. Statins have potent anti-inflammatory properties but these cannot be fully exploited with oral statin therapy due to low systemic bioavailability. Here we present an injectable reconstituted high-density lipoprotein (rHDL) na...

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Bibliografiska uppgifter
Huvudupphovsmän: Duivenvoorden, Raphaël, Tang, Jun, Cormode, David P., Mieszawska, Aneta J., Izquierdo-Garcia, David, Ozcan, Canturk, Otten, Maarten J., Zaidi, Neeha, Lobatto, Mark E., van Rijs, Sarian M., Priem, Bram, Kuan, Emma L., Martel, Catherine, Hewing, Bernd, Sager, Hendrik, Nahrendorf, Matthias, Randolph, Gwendalyn J., Stroes, Erik S.G., Fuster, Valentin, Fisher, Edward A., Fayad, Zahi A., Mulder, Willem J.M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001802/
https://ncbi.nlm.nih.gov/pubmed/24445279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4065
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