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Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression
Pancreatic ductal adenocarcinoma (PDAC) is strikingly resistant to conventional therapeutic approaches. We previously demonstrated that the histone deacetylase–associated protein SIN3B is essential for oncogene-induced senescence in cultured cells. Here, using a mouse model of pancreatic cancer, we...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4001548/ https://ncbi.nlm.nih.gov/pubmed/24691445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72619 |
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