Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer

The epithelial-to-mesenchymal transition (EMT) transcriptional program is characterized by repression of E-cadherin (CDH1) and induction of N-cadherin (CDH2), and mesenchymal genes like vimentin (VIM). Placenta-specific 8 (PLAC8) has been implicated in colon cancer; however, how PLAC8 contributes to...

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Detalhes bibliográficos
Main Authors: Li, Cunxi, Ma, Haiting, Wang, Yang, Cao, Zheng, Graves-Deal, Ramona, Powell, Anne E., Starchenko, Alina, Ayers, Gregory D., Washington, Mary Kay, Kamath, Vidya, Desai, Keyur, Gerdes, Michael J., Solnica-Krezel, Lila, Coffey, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001536/
https://ncbi.nlm.nih.gov/pubmed/24691442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71103
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